Seung Kim Laboratory


Stanford School of Medicine
Stanford University
Stanford University


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Kim Lab





Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK. 2017. Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nature Communications. 8(8): 14686.

- Research Highlight: Pancreatic cancer, diabetes link explored by Stanford researchers. Scope-Stanford Medicine.

Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK. 2017. Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. Cell Metabolism. 25(3):622-634.

- Research Highlight: Pancreatic islet cells in animals can 'flip' their fate to produce insulin. Stanford Medicine News Center.

- Research Highlight: Should I Stay or Should I Go: A Clash of α-Cell Identity. Remedi MS. Cell Metabolism. 25(7):488-490.

Wang Y, Galivo F, Pelz C, Haft A, Lee J, Kim SK, Grompe M. 2016. Efficent generation of pancreatic beta-like cells from the mouse gallbladder. Stem Cell Research. 17(3):587-596.

Kockel L, Huq LM, Ayyar A, Herold E, MacAlpine E, Logan M, Savvides C, Kim GE, Chen J, Clark T, Duong T, Fazel-Rezai V, Havey D, Han S, Jagadeesan R, Kim ES, Lee D, Lombardo K, Piyale I, Shi H, Stahr L, Tung D, Tayvah U, Wang F, Wang JH, Xiao S, Topper SM, Park S, Rotondo C, Rankin AE, Chisholm TW, Kim SK. 2016. A Drosophila LexA enhancer-trap resource for developmental biology and neuroendocrine research. G3: Genes,Genomes, Genetics. 13:6(10):3017-3026.

- Research Highlight: 'Ultimately about discovery': High-school students experience hands-on biology research. Scope-Stanford Medicine.

- Research Highlight: Synergy and Science. Exeter Bulletin Fall 2016.

Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK. 2016. Gestational diabetes from inactivation of prolactin receptor and MafB in islet beta cells. Diabetes. 65(8):2331-2341.

Kim SK, Baldwin K, Gao S, Bucker C, Parmar M, Benvenisty N. 2016. iPSCs: 10 years and counting. Cell. 165(5):1041-1042

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. 2016. Age-dependent pancreatic gene regulation reveals mechanisms governing human beta-cell function. Cell Metabolism. 23(5):909-920.

- Research Highlight: 2016, Age-dependent changes in pancreatic function related to diabetes identified. Stanford Medicine News Center.

- Research Highlight: F1000Prime Recomendation. Gloyn A, Thomsen S. 09 May 2016; DOI: 10.3410

Alfa RW, Kim SK. 2016. Using Drosophila to discover mechanisms underlying type 2 diabetes. Disease Models and Mechanisms. 9(1):365-376.

Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK. 2016. Research Resource: Genetic labelling of human islet alpha cells. Molecular Endocrinology. 30(2):248-253.

Leung TH, Snyder ER, Liu Y, Wang J, Kim SK. 2015. A cellular, molecular, and pharmacological basis for appendage regeneration in mice. Genes and Development. 29(20):2097-2107.

- Research Highlight: 2015, How mice regrow ear tissue. Nature. 527, 136-137 doi:10.1038/527136d

Chiou SH, Winters IP, Wang J, Naranjo S, Dudgeon C, Tamburini FB, Brady JJ, Yang D, Gruner BM, Chuang CH, Caswell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, Winslow MM. 2015. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas-9 mediated somatic genome editing. Genes and Development. 29(14):1576-85.

Pauerstein PT, Sugiyama T, Stanley SE, McLean GW, Wang J, Martin MG, Kim SK. 2015. Dissecting human gene functions regulating islet development with targeted gene transduction. Diabetes. 64(8):3037-49.

Alfa RW, Park S, Skelly KR, Poffenberger G, Jain N, Gu X, Kockel L, Wang J, Liu Y, Powers AC, Kim SK. 2015. Suppression of Insulin Production and Secretion by a Decretin Hormone. Cell Metab. 21(2):323-333.

- Research Highlight: Crunkhorn S. 2015, Novel decretin hormone identified. Nature Reviews Drug Discovery. 14, 238 doi:10.1038/nrd4601

- Research Highlight: 2015, Limostatin—a decretin—suppresses insulin production Nature Reviews Endocrinology. 11, 194 doi:10.1038/nrendo.2015.20

- Editors' Choice: Gough NR. 2015, Finding the decretin hormone. Sci. Signal. 8, ec29

Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. 2015. Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations. PLoS One 23, 10:e0118449. doi: 10.1371/journal.pone.0118449.

Sebastiano V, Zhen HH, Derafshi BH, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, Schwertschkow A, Bauer G, Lisowski L, Kay MA, Kim SK, Lane AT, Wernig M, Oro AE. 2014. Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. Sci. Transl. Med. 6(264):264ra163.

Benitez CM, Qu K, Sugiyama T, Pauerstein PT, Liu Y, Tsai J, Gu X, Ghodasara A, Arda HE, Zhang J, Dekker JD, Tucker HO, Chang HY, Kim SK. 2014. An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development. PLoS Genet 10:e1004645.

Park S, Alfa RW, Topper SM, Kim GE, Kockel L, Kim SK. 2014. A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion. PLoS Genet 10:e1004555.

Cao J, Ni J, Ma W, Shiu V, Milla LA, Park S, Spletter ML, Tang S, Zhang J, Wei X, Kim SK, Scott MP. 2014. Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila. Genetics 197:175-92.

Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. 2013. Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice. J Clin Invest. 123:5361–5370

Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann JF, Miyazaki S, Miyazaki J, Szot GL, Bottino R, Kim SK. 2013. Expansion and Conversion of Human Pancreatic Ductal Cells into Insulin-Secreting Endocrine Cells. eLife. 2:e00940

Zhou JX, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, Kim SK, Bhushan A 2013. Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J Clin Invest. 123(11):4849–4858

Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CVE, Gu G, and Kim SK. 2013. Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc. Natl. Acad. Sci. USA, 110(31):12691-6

Arda HE, Benitez CM, Kim SK. 2013. Gene Regulatory Networks Governing Pancreas Development. Dev Cell. 25:5-13

Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. 2012. Neonatal β-Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT. Dev Cell. 23:21-34

- Previews : Kragl M, Lammert E. 2012. Calcineurin/NFATc Signaling: Role in Postnatal β-Cell Development and Diabetes Mellitus. Dev Cell. 23:7-8

Benitez CM, Goodyer WR, Kim SK. 2012. Deconstructing Pancreas Developmental Biology. Cold Spring Harb Perspect Biol. 4:a012401

Kim SK. 2012. Gut insulin from Foxo1 loss. Nat Genet. 44(4):363-4

Wang P, McKnight KD, Wong DJ, Rodriguez RT, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang HY, Kim SK. 2012. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 21(12):2273-87

Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK. 2011. PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature. 478(7369):349-55

Park S, Bustamante EL, Antonova J, McLean GM, Kim SK. 2011. Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm is Regulated by Notch Signaling. PLoS Genetics. 7(8):e1002241.

Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerød A, Børresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY. 2011. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 43(7):621-9.

Wang P, Rodriguez RT, Wang J, Ghodasara A, Kim SK. 2011. Targeting SOX17 in Human Embryonic Stem Cells Creates Unique Strategies for Isolating and Analyzing Developing Endoderm. Cell Stem Cell. 8(3):335-46.

McKnight KD, Wang P, Kim SK. 2010. Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell. 6(4):300-8.

Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, and Kim SK. 2009. Polycomb protein Ezh2 regulates pancreatic ß-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes & Development. 23(8):975-85

Sugiyama T and Kim SK. 2008. Fluorescence-activated cell sorting purification of pancreatic progenitor cells. Diabetes Obes Metab. Suppl 4:179-85.

S. L. Chavez, J. J. Meneses, H. N. Nguyen, S. K. Kim, R. A. Pera. 2008. Characterization of Six New Human Embryonic Stem Cell Lines (HSF7, -8, -9, -10, -12, and -13) Derived Under Minimal-Animal Component Conditions. Stem Cells Dev. 17(3):535-546.

S. K. Karnik, H. Chen, G. W. McLean, J. J. Heit, X. Gu, A. Y. Zhang, M. Fontaine, M. H. Yen, and S. K. Kim. 2007. Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus . Science, 318(5851):806-809 . Full Text

P. La, Y. Yang, S.K. Karnik, A.C. Silva, R.W. Schnepp, S.K. Kim, X. Hua. 2007. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J. Biol.Chem., 282(43):31332-40.

I.C. Rulifson, S.K. Karnik, P.W. Heiser, D. Ten Berge, H. Chen, X. Gu, M.M. Taketo, R. Nusse, M. Hebrok and S.K. Kim. 2007. Wnt signaling regulates pancreatic beta cell proliferation. Proc. Natl. Acad. Sci. USA, 104:6247-6252.

L.C. Alonso, T. Yokoe, P. Zhang, D.K. Scott, S.K. Kim, C.P. O'Donnell, A. Garcia-Ocana. 2007. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes, 56(7):1792-801

T. Sugiyama, R.T. Rodriguez, G.W. McLean and S.K. Kim. 2006. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc. Natl. Acad. Sci. USA , 104: 175-180.

J.J. Heit, Å.A. Apelqvist, X. Gu, M.M. Winslow, J.R. Neilson, G.R. Crabtree and S.K. Kim. 2006. Calcineurin/NFAT signaling regulates pancreatic ß-cell growth and function. Nature, 443: 345-349.

J.J. Heit, S.K. Karnik, and S.K. Kim. 2006. Intrinsic regulators of pancreatic ß-cell proliferation. Annual Reviews of Cell and Developmental Biology, 22: 311-338.

T. Akasaka, S. Klinedinst, K. Ocorr, E.L. Bustamante, S.K. Kim and R. Bodmer. 2006. KATP channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc. Natl. Acad. Sci. USA, 103: 11999-12004.

J.R. Arron, M.M. Winslow, A Polleri, C.P. Chang, H. Wu, X. Gao, J. R. Neilson, L. Chen, J.J. Heit, S.K. Kim, N. Yamasaki, T. Miyakawa, U. Franke, I.A. Graef, and G.R. Crabtree. 2006. NFAT dysregulation by increased dosage of DSCR1 and DYRK1 on chromosome 21. Nature, 441: 595-600.

N.G. Smart, Å.A. Apelqvist, X. Gu, E.B. Harmon, J.N. Topper, R.J. MacDonald, and S.K. Kim. 2006. Conditional expression of Smad7 in pancreatic ß-cells disrupts TGF-ß signaling and induces reversible diabetes mellitus. PLoS Biol., 4: e39.

S.K. Karnik, C.M. Hughes, X. Gu, O. Rozenblatt-Rosen, G.W. McLean, Y. Xiong, M. Meyerson, and S.K. Kim. 2005. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl. Acad. Sci. USA 102: 14659-14664.

Y. Hori, X. Gu, X. Xie, and S.K. Kim. 2005. Differentiation of Insulin-Producing Cells from Human Neural Progenitor Cells. PLoS Med., 2: e103.

J.J. Heit and S.K. Kim. 2004. Embryonic stem cells and islet replacement in diabetes mellitus. Pediatric Diabetes, Suppl 2: 5-15.

E.B. Harmon, Å. Apelqvist, N. Smart, X. Gu, D. Osborne, and S.K. Kim. 2004. GDF11 modulates NGN3+ islet progenitor cell number and promotes ß-cell differentiation in pancreas development. Development, 131: 6163-6174.

S.K. Kim and E.J. Rulifson. 2004. Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature 431: 316-420.

Y. Hori, I.C. Rulifson, B.C. Tsai, J.J. Heit, J.D. Cahoy, and S.K. Kim. 2002. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc. Natl. Acad. Sci. USA 99: 16105-16110.

S.K. Kim and R. MacDonald. 2002. Signaling and transcriptional regulation in the developing pancreas. Current Opinion in Genetics & Development 12: 540-547.

S.K. Kim. 2002. "Pancreatic Islet Cell Replacement: Successes and Opportunities" in Reparative Medicine: Growing Organs and Tissues, J.D. Sipe, C.A. Kelley, and L.A. McNichol, eds., Ann. N.Y. Acad. Sci. 961: 1-3.

E.J. Rulifson, S.K. Kim, and R. Nusse. 2002. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science, 296: 1118-1120.

S.K. Kim, L. Selleri, J.S. Lee, A. Zhang, X. Gu, Y. Jacobs, and M.L. Cleary. 2002. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nature Genetics, 30: 430-435.

E. Harmon, A. Ko, and S.K. Kim. 2002. Hedgehog signaling in gastrointestinal development and disease. Current Molecular Medicine 2: 67-82.

S.K. Kim and M. Hebrok. 2001. Intercellular Signals Regulating Pancreas Development and Function. Genes & Development, 15: 111-127.

M. Hebrok, S.K. Kim, B. St.-Jacques, A.P. McMahon, and D. A. Melton. 2000. Regulation of pancreas development by Hedgehog signaling. Development, 127: 4905-4913.

S.K. Kim, M. Hebrok, E. Li, S. P. Oh, H. Schrewe, E. B. Harmon, J. S. Lee, and D. A. Melton. 2000. Activin receptor patterning of foregut organogenesis. Genes & Development, 14: 1866-1871.

M. Hebrok, S.K. Kim, and D. A. Melton. 1999. Effects of hedgehog signaling on pancreas development. Falk Symposium 113, Conference Proceedings. “Cytokines and homeostasis in the gastrointestinal tract.” pp. 379-387.

M. Hebrok, S.K. Kim, and D.A. Melton. 1999. Screening for novel pancreatic genes expressed during embryogenesis. Diabetes, 48: 1550-1556.

M. Hebrok, S.K. Kim and D. A. Melton. 1998. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes and Development, 12: 1705-1713.

S.K. Kim and D. A. Melton. 1998. Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA 95: 13036-13041.

S.K. Kim, M. Hebrok and D. A. Melton. 1997. Pancreas development in the chick embryo, in Cold Spring Harbor Symposia on Quantitative Biology. 62: 377-383.

S.K. Kim, M. Hebrok and D. A. Melton. 1997. Notochord to endoderm signaling is required for pancreas development. Development, 124: 4243-4252.

S.K. Kim and G. Demetri. 1996. Chemotherapy and Neutropenia. Hematology and Oncology Clinics of North America 10: 377-395.

S.K. Kim. 1992. C-factor: An intercellular signaling protein required for fruiting body morphogenesis of Myxococcus xanthus. Doctoral thesis. Department of Biochemistry, Stanford University.

S.K. Kim, A. Kuspa and D. Kaiser. 1992. Control of cell density and pattern by intercellular signaling in Myxococcus development. Annual Reviews of Microbiology, 46:117-139.

S.K. Kim. 1991. Intercellular signaling in Myxococcus development: the role of C-factor. Trends in Genetics, 7: 361-365.

S.K. Kim and D. Kaiser. 1991. C-factor has distinct aggregation and sporulation thresholds during Myxococcus development. Journal of Bacteriology, 173: 1722-1728.

S.K. Kim and D. Kaiser. 1990. Cell alignment required in differentiation of Myxococcus xanthus. Science, 249: 926-928.

S.K. Kim and D. Kaiser. 1990. Cell motility is required for the transmission of C-factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. Genes and Development, 4: 896-904.

S.K. Kim and D. Kaiser. 1990. Purification and properties of Myxococcus xanthus C-factor, an intercellular signaling protein. Proc. Natl. Acad. Sci. USA 87: 3635-9.

S.K. Kim and D. Kaiser. 1990. C-factor: A cell-cell signaling protein required for fruiting body morphogenesis of Myxococcus xanthus. Cell, 61: 19-26.

R. Lagos, R.-Z. Jiang, S. Kim and R. Goldstein. 1986 Rho-dependent transcription termination of a bacterial operon is antagonized by an extrachromosomal gene product. Proc. Natl. Acad. Sci., USA 83: 1561-5.




Seung Kim Lab Meeting & Journal Club Schedule