Publications
 

• Coykendall VMN, Qian MF, Tellez K, Bautista A, Bevacqua RJ, Gu X, Hang Y, Neukam M, Zhao W, Chang C, MacDonald PE, Kim SK. RFX6 maintains gene expression and function of adult human islet α cells. 2023. Diabetes, db230483. https://doi: 10.2337/db23-0483.

• Rankin AE, Fox E, Chisholm T, Lantz N, Rajan A, Phillips W, Griffin E, Harper J, Suhr C, Tan M, Wang J, Yang A, Kim ES, Ankrah NKA, Chakraborty P, Lam ACK, Laws ME, Lee J, Park KK, Wesel E, Covert PH, Kockel L, Park S, Kim SK. Simplified homology-assisted CRISPR for gene editing in Drosophila. 2023. G3. https://doi: 10.1093/g3journal/jkad277.

• Qian MF, Bevacqua RJ, Coykendall VM, Liu X, Zhao W, Chang CA, Gu X, Dai XQ, MacDonald PE, Kim SK. HNF1α maintains pancreatic α and β cell functions in primary human islets. 2023. JCI Insight. e170884.

• Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. 2023. Nat Genet 55, 54–65. https://doi.org/10.1038/s41588-022-01261-2

• Bevacqua RJ, Zhao W, Merheb E, Kim SH, Marson A, Gloyn AL, Kim SK. Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein. 2023. bioRxiv [Preprint]. iScience, in press.

• Kim ES, Rajan A, Chang K, Govindarajan S, Gulick C, English E, Rodriguez B, Bloomfield O, Nakada S, Beard C, O'Connor S, Mastroianni S, Downey E, Feigenbaum M, Tolentino C, Pace A, Khan M, Moon S, DiPrima J, Syed A, Lin F, Abukhadra Y, Bacon I, Beckerle J, Cho S, Donkor NE, Garberg L, Harrington A, Hoang M, Lawani N, Noori A, Park E, Parsons E, Oravitan P, Chen M, Molina C, Richmond C, Reddi A, Huang J, Shugrue C, Coviello R, Unver S, Indelicarto M, Islamovic E, McIlroy R, Yang A, Hamad M, Griffin E, Ahmed Z, Alla A, Fitzgerald P, Choi A, Das T, Cheng Y, Yu J, Roderiques T, Lee E, Liu L, Harper J, Wang J, Suhr C, Tan M, Luque J, Tam AR, Chen E, Triff M, Zimmermann L, Zhang E, Wood J, Clark K, Kpodonu N, Dey A, Ecker A, Chuang M, López RKS, Sun H, Wei Z, Stone H, Chi CYJ, Silvestri A, Orloff P, Nedumaran N, Zou A, Ünver L, Page O, Kim M, Chan TYT, Tulloch A, Hernandez A, Pillai A, Chen C, Chowdhury N, Huang L, Mudide A, Paik G, Wingate A, Quinn L, Conybere C, Baumgardt LL, Buckley R, Kolberg Z, Pattison R, Shazli AA, Ganske P, Sfragara L, Strub A, Collier B, Tamana H, Ravindran D, Howden J, Stewart M, Shimizu S, Braniff J, Fong M, Gutman L, Irvine D, Malholtra S, Medina J, Park J, Yin A, Abromavage H, Barrett B, Chen J, Cho R, Dilatush M, Gaw G, Gu C, Huang J, Kilby H, Markel E, McClure K, Phillips W, Polaski B, Roselli A, Saint-Cyr S, Shin E, Tatum K, Tumpunyawat T, Wetherill L, Ptaszynska S, Zeleznik M, Pesendorfer A, Nolan A, Tao J, Sammeta D, Nicholson L, Dinh GV, Foltz M, Vo A, Ross M, Tokarski A, Hariharan S, Wang E, Baziuk M, Tay A, Wong YHM, Floyd J, Cui A, Pierre K, Coppisetti N, Kutam M, Khurjekar D, Gadzi A, Gubbay B, Pedretti S, Belovich S, Yeung T, Fey M, Shaffer L, Li A, Beritela G, Huyghue K, Foster G, Durso-Finley G, Thierfelder Q, Kiernan H, Lenkowsky A, Thomas T, Cheng N, Chao O, L'Etoile-Goga P, King A, McKinley P, Read N, Milberg D, Lin L, Wong M, Gilman I, Brown S, Chen L, Kosai J, Verbinsky M, Belshaw-Hood A, Lee H, Zhou C, Lobo M, Tse A, Tran K, Lewis K, Sonawane P, Ngo J, Zuzga S, Chow L, Huynh V, Yang W, Lim S, Stites B, Chang S, Cruz-Balleza R, Pelta M, Kujawski S, Yuan C, Standen-Bloom E, Witt O, Anders K, Duane A, Huynh N, Lester B, Fung-Lee S, Fung M, Situ M, Canigiula P, Dijkgraaf M, Romero W, Baula SK, Wong K, Xu I, Martinez B, Nuygen R, Norris L, Nijensohn N, Altman N, Maajid E, Burkhardt O, Chanda J, Doscher C, Gopal A, Good A, Good J, Herrera N, Lanting L, Liem S, Marks A, McLaughlin E, Lee A, Mohr C, Patton E, Pyarali N, Oczon C, Richards D, Good N, Goss S, Khan A, Madonia R, Mitchell V, Sun N, Vranka T, Garcia D, Arroyo F, Morales E, Camey S, Cano G, Bernabe A, Arroyo J, Lopez Y, Gonzalez E, Zumba B, Garcia J, Vargas E, Trinidad A, Candelaria N, Valdez V, Campuzano F, Pereznegron E, Medrano J, Gutierrez J, Gutierrez E, Abrego ET, Gutierrez D, Ortiz C, Barnes A, Arms E, Mitchell L, Balanzá C, Bradford J, Detroy H, Ferguson D, Guillermo E, Manapragada A, Nanula D, Serna B, Singh K, Sramaty E, Wells B, Wiggins M, Dowling M, Schmadeke G, Cafferky S, Good S, Reese M, Fleig M, Gannett A, Cain C, Lee M, Oberto P, Rinehart J, Pan E, Mathis SA, Joiner J, Barr L, Evans CJ, Baena-Lopez A, Beatty A, Collette J, Smullen R, Suttie J, Chisholm T, Rotondo C, Lewis G, Turner V, Stark L, Fox E, Amirapu A, Park S, Lantz N, Rankin AE, Kim SK, Kockel L. Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network. 2023. G3 Genes|Genomes|Genetics (Bethesda). 13(9):jkad124.

• Wang G, Chiou J, Zeng C, Miller M, Matta I, Han JY, Kadakia N, Okino ML, Beebe E, Mallick M, Camunas-Soler J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes. 2023. Nature Genetics. 55(6):984-994.

• Mello SS, Flowers BM, Mazur PK, Lee J, Muller F, Denny SK, Ferreira S, Hanson KJ, Kim SK, Greenleaf W, Wood LD, Attardi LD. Multifaceted role for p53 in pancreatic cancer suppression. 2023. Proceedings of the National Academy of Sciences. 120(10):e2211937120.

• Tsao DD, Chang KR, Kockel L, Park S, Kim SK. A genetic strategy to measure insulin signaling regulation and physiology in Drosophila. 2023. PLoS Genetics. 19(2):e1010619.

• Marquez-Curtis LA, Dai XQ, Hang Y, Lam JY, Lyon J, Manning Fox JE, McGann LE, MacDonald PE, Kim SK, Elliott JAW. Cryopreservation and post-thaw characterization of dissociated human islet cells. 2022. PLoS One. 17(1):e0263005.

• Chang CA, Bhagchandani P, Poyser J, Valesco BJ, Zhao W, Kwon H, Meyer E, Shizuru JA, Kim SK. Curative islet and hematopoeitic cell transplantation in diabetic mice without toxic bone marrow conditioning. 2022. Cell Reports. 41(6): 11165. [PDF]

  • Preview: Bone marrow chimerism breaks the barrier to pancreatic islet transplantation. 2022. Cell Reports. 41(7): 111692. [PDF]

• The Tabula Sapiens Consortium. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. 2022. Science. 376(6594): eabl4896.

• Duvall E, Benitez CM, Tellez K, Enge M, Pauerstein PT, Li L, Baek S, Quake SR, Smith JP, Sheffield NC, Kim SK, Arda HE. Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development. 2022. Proceedings of the National Academy of Sciences. 119(26):e2201267119. [PDF]

• Bhagchandani P, Chang CA, Zhao W, Ghila L, Herrera PL, Chera S, Kim SK. Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes. 2022. Scientific Reports. 12: 9033.

• Li H, Janssens J, De Waegeneer M, Kolluru SS, Davie K, Gardeux V, Saelens W, David FPA, Brbić M, Spanier K, Leskovec J, McLaughlin CN, Xie Q, Jones RC, Brueckner K, Shim J, Tattikota SG, Schnorrer F, Rust K, Nystul TG, Carvalho-Santos Z, Ribeiro C, Pal S, Mahadevaraju S, Przytycka TM, Allen AM, Goodwin SF, Berry CW, Fuller MT, White-Cooper H, Matunis EL, DiNardo S, Galenza A, O'Brien LE, Dow JAT; FCA Consortium§, Jasper H, Oliver B, Perrimon N, Deplancke B, Quake SR, Luo L, Aerts S, Agarwal D, Ahmed-Braimah Y, Arbeitman M, Ariss MM, Augsburger J, Ayush K, Baker CC, Banisch T, Birker K, Bodmer R, Bolival B, Brantley SE, Brill JA, Brown NC, Buehner NA, Cai XT, Cardoso-Figueiredo R, Casares F, Chang A, Clandinin TR, Crasta S, Desplan C, Detweiler AM, Dhakan DB, Donà E, Engert S, Floc'hlay S, George N, González-Segarra AJ, Groves AK, Gumbin S, Guo Y, Harris DE, Heifetz Y, Holtz SL, Horns F, Hudry B, Hung RJ, Jan YN, Jaszczak JS, Jefferis GSXE, Karkanias J, Karr TL, Katheder NS, Kezos J, Kim AA, Kim SK, Kockel L, Konstantinides N, Kornberg TB, Krause HM, Labott AT, Laturney M, Lehmann R, Leinwand S, Li J, Li JSS, Li K, Li K, Li L, Li T, Litovchenko M, Liu HH, Liu Y, Lu TC, Manning J, Mase A, Matera-Vatnick M, Matias NR, McDonough-Goldstein CE, McGeever A, McLachlan AD, Moreno-Roman P, Neff N, Neville M, Ngo S, Nielsen T, O'Brien CE, Osumi-Sutherland D, Özel MN, Papatheodorou I, Petkovic M, Pilgrim C, Pisco AO, Reisenman C, Sanders EN, Dos Santos G, Scott K, Sherlekar A, Shiu P, Sims D, Sit RV, Slaidina M, Smith HE, Sterne G, Su YH, Sutton D, Tamayo M, Tan M, Tastekin I, Treiber C, Vacek D, Vogler G, Waddell S, Wang W, Wilson RI, Wolfner MF, Wong YE, Xie A, Xu J, Yamamoto S, Yan J, Yao Z, Yoda K, Zhu R, Zinzen RP. Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. 2022. Science. 375(6584): eabk2432.

• Wendler F, Park S, Hill C, Galasso A, Chang KR, Awan I, Sudarikova Y, Bustamante M, Liu S, Sung E, Aisabonoko G, Kim SK, Baena-Lopez LA. A toolkit to generate inducible and interconvertible Drosophila transgenes. 2022. Scientific Reports. 12: 3835.

• Dai X, Camunas-Soler J, Briant LJB, dos Santos T, Spigelman AF, Walker EM, e Drigo RA, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Fox JEM, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state. 2022. Cell Metabolism. 34(2): 256-268.e5 [PDF]

• Chang KR, Tsao DD, Bennett C, Wang E, Floyd JF, Tay ASY, Greenwald E, Kim ES, Griffin C, Morse E, Chisholm T, Rankin AE, Baena-Lopez LA, Lantz N, Fox E, Kockel L, Kim SK, Park S. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. 2022. G3 Genes|Genomes|Genetics. jkac018. [PDF]

• Kaestner KH, Campbell-Thompson M, Dor Y, Gill RG, Glaser B, Kim SK, Sander M, Stabler C, Stewart AF, Powers AC. What is a β cell? — Chapter I in the Human Islet Research Network (HIRN) review series. 2021. Molecular Metabolism. 53:101323. [PDF]

• Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. 2021. Genes & Development. Available online. [PDF]

• Kim SK, Tsao DD, Suh GSB, Miguel-Aliaga I. Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila. 2021. Cell Metabolism. Available online. [PDF]

• Friedlander MSH, Nguyen VM, Kim SK, Bevacqua RJ. Pancreatic pseudoislets: an organoid archetype for metabolism research. 2021. Diabetes. 2021 May 4:db201115. [PDF]

• Bevacqua RJ, Dai X, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonàs-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK. CRISPR-based genome editing in primary human pancreatic islet cells. 2021. Nature Communications. 12, 2397 (2021).

  • Perspective: A commentary by Romina Bevacqua. Nature Portfolio Bioengineering Community 2021.

• Bevacqua RJ, Lam JY, Peiris H, Whitener RL, Kim S, Gu X, Friedlander MSH, Kim SK. SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. 2021. Genes & Development. 35: 234-249.

• Tosti L, Hang Y, Debnath O, Tiesmeyer S, Trefzer T, Steiger K, Ten FW, Lukassen S, Ballke S, Kühl AA, Spieckermann S, Bottino R, Ishaque N, Weichert W, Kim SK, Eils R, Conrad C. Single nucleus and in situ RNA sequencing reveals cell topographies in the human pancreas. 2020. Gastroenterology. 160(4): 1330-1344.e11.

• The Tabula Muris Consortium. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. 2020. Nature. 583: 590-595.

• Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M, The Tabula Muris Consortium, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Ageing hallmarks exhibit organ-specific temporal signatures. 2020. Nature. 583: 596-602.

• Tellez K, Hang Y, Gu X, Stein RW, Kim SK. In vivo studies of glucagon secretion by human islets transplanted in mice. 2020. Nature Metabolism. 2(6): 547-557.

• Moon JH, Kim H, Kim H, Park J, Choi W, Choi W, Hong HJ, Ro HJ, Jun S, Choi SH, Banerjee RR, Shong M, Cho NH, Kim SK, German MS, Jang HC, Kim H. Lactation improves pancreatic β cell mass and function through serotonin production. 2020. Science Translational Medicine. 12(541):eaay0455.

• Camunas-Soler J, Dai X, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE. Patch-seq links single-cell transcriptomes to human islet dysfunction in diabetes. 2020. Cell Metabolism. 31(5): 1017-1031.

  • Preview: From the Transcriptome to Electrophysiology: Searching for the Underlying Cause of Diabetes. 2020. Cell Metabolism 31(5): 888-889.

• Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong J, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H. Serotonin regulates adult β-cell mass by stimulating perinatal β-cell proliferation. 2020. Diabetes. 69(2): 205-214.

• Kim S, Whitener RL, Peiris H, Gu X, Chang CA, Lam JY, Camunas-Soler J, Park I, Bevaqua RJ, Tellez K, Quake SR, Lakey JRT, Bottino R, Ross PJ, Kim SK. Molecular and genetic regulation of pig pancreatic islet cell development. 2020. Development. 147: dev186213.

  • Research Highlight: Pancreas development in pigs. Development 2020 147: e0604.

• Liu R, Mignardi M, Jones R, Enge M, Kim SK, Quake SR, Zou J. Modeling spatial correlation of transcripts with application to developing pancreas. 2019. Scientific Reports. DOI: 10.1038/s41598-019-41951-2.

• Kockel L, Griffin C, Ahmed Y, Fidelak L, Rajan A, Gould EP, Haigney M, Ralston B, Tercek RJ, Galligani L, Rao S, Huq L, Bhargava HK, Dooner AC, Lemmerman EG, Malusa RF, Nguyen TH, Chung JS, Gregory SM, Kuwana KM, Regenold JT, Wei A, Ashton J, Dickinson P, Martel K, Cai C, Chen C, Price S, Qiao J, Shepley D, Zhang J, Chalasani M, Nguyen K, Aalto A, Kim B, Tazawa-Goodchild E, Sherwood A, Rahman A, Wu SYC, Lotzkar J, Michaels S, Aristotle H, Clark A, Gasper G, Xiang E, Schlör FL, Lu M, Haering K, Friberg J, Kuwana A, Lee J, Liu A, Norton E, Hamad L, Lee C, Okeremi D, diTullio H, Dumoulin K, Chi SYG, Derossi GS, Horowitch RE, Issa EC, Le DT, Morales BC, Noori A, Shao J, Cho S, Hoang MN, Johnson IM, Lee KC, Lee M, Madamidola EA, Schmitt KE, Byan G, Park T, Chen J, Monovoukas A, Kang MJ, McGowan T, Walewski JJ, Simon B, Zu SJ, Miller GP, Fitzpatrick KB, Lantz N, Fox E, Collette J, Kurtz R, Duncan C, Palmer R, Rotondo C, Janicki E, Chisholm T, Rankin A, Park S, Kim SK. An Interscholastic Network to Generate LexA Enhancer Trap Lines in Drosophila. 2019. G3 (Bethesda). DOI: 10.1534/g3.119.400105.

• Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK. Discovering human diabetes-risk gene function with genetics and physiological assays. 2018. Nature Communications. 9:3855.

• Arda HE, Tsai J, Rosli YR, Giresi P, Bottino R, Greenleaf WJ, Chang HY, Kim SK. A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. 2018. Cell Systems. DOI: https://doi.org/10.1016/j.cels.2018.07.007.

• Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC. The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. 2018. Pancreas. 47(5):516-525.

• Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim SK, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe’er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, Van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N. The Human Cell Atlas. 2017. eLife. 6:e27041.

• The Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. 2018. Nature. DOI: https://doi.org/10.1038/s41586-018-0590-4.

• Pierini A, Iliopoulou BP, Peiris H, Pérez-Cruz M, Baker J, Hsu K, Gu X, Zheng PP, Erkers T, Tang SW, Strober W, Alvarez M, Ring A, Velardi A, Negrin RS, Kim SK, Meyer EH. T cells expressing chimeric antigen receptor promote immune tolerance. 2017. Journal of Clinical Investigation Insight. 10:2(20).

  • Research Highlight: Genetic Engineering of immune cells to advance cell therapies for T1D. Helmsley Trust News.

• Pauerstein PT, Tellez K, Willmarth KB, Park KM, Hsueh B, Efsun Arda H, Gu X, Aghajanian H, Deisseroth K, Epstein JA, Kim SK. A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis. 2017. Development. 144(20):3744-3754.

  • Research Highlight: Semaphorin marks the spot in the pancreas. Development 2017 144: e2003

• Mello S, Valente L, Raj N, Seoane J, Flowers B, McClendon J, Bieging-Rolett K, Lee J, Ivanochko D, Kozak M, Chang D, Longacre T, Koong A, Arrowsmith C, Kim SK, Vogel H, Wood L, Hruban R, Curtis C, Attardi L. A p53 super-tumor suppressor reveals a tumor suppressive p53-Ptpn14-Yap axis in pancreatic cancer. 2017. Cancer Cell. 32(4):460-473.

• Enge M, Arda HE, Mignardi M, Beausang J, Bottino R, Kim SK, Quake SR. Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns. 2017. Cell. 171(2):321-330.

  • Research Preview: Transcriptional Noise and Somatic Mutations in the Aging Pancreas. Cell Metabolism. 26(6):809-811.

• Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC. 2017. Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. 2017. Journal of Clinical Investigation. 127(10):3835-3844.

  • Research Highlight: Pancreatic islets study may spur diabetes treatment advances. Vanderbilt University Research News.

• Hsueh B, Burns VM, Pauerstein P, Holzem K, Ye L, Engberg K, Wang AC, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, Efimov IR, Kim SK, Deisseroth K. 2017. Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease. Scientific Reports. 7(1): 5899.

• Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK. 2017. Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nature Communications. 8(8): 14686.

  • Research Highlight: Pancreatic cancer, diabetes link explored by Stanford researchers. Scope-Stanford Medicine.

• Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK. 2017. Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. Cell Metabolism. 25(3):622-634.

  • Research Highlight: Pancreatic islet cells in animals can 'flip' their fate to produce insulin. Stanford Medicine News Center.

  • Research Highlight: Should I Stay or Should I Go: A Clash of α-Cell Identity. Remedi MS. Cell Metabolism. 25(7):488-490.

• Wang Y, Galivo F, Pelz C, Haft A, Lee J, Kim SK, Grompe M. 2016. Efficent generation of pancreatic beta-like cells from the mouse gallbladder. Stem Cell Research. 17(3):587-596.

• Kockel L, Huq LM, Ayyar A, Herold E, MacAlpine E, Logan M, Savvides C, Kim GE, Chen J, Clark T, Duong T, Fazel-Rezai V, Havey D, Han S, Jagadeesan R, Kim ES, Lee D, Lombardo K, Piyale I, Shi H, Stahr L, Tung D, Tayvah U, Wang F, Wang JH, Xiao S, Topper SM, Park S, Rotondo C, Rankin AE, Chisholm TW, Kim SK. 2016. A Drosophila LexA enhancer-trap resource for developmental biology and neuroendocrine research. G3: Genes,Genomes, Genetics. 13:6(10):3017-3026.

  • Research Highlight: 'Ultimately about discovery': High-school students experience hands-on biology research. Scope-Stanford Medicine.

  • Research Highlight: Synergy and Science. Exeter Bulletin Fall 2016.

• Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK. 2016. Gestational diabetes from inactivation of prolactin receptor and MafB in islet beta cells. Diabetes. 65(8):2331-2341.

• Kim SK, Baldwin K, Gao S, Bucker C, Parmar M, Benvenisty N. 2016. iPSCs: 10 years and counting. Cell. 165(5):1041-1042

• Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. 2016. Age-dependent pancreatic gene regulation reveals mechanisms governing human beta-cell function. Cell Metabolism. 23(5):909-920.

  • Research Highlight: 2016, Age-dependent changes in pancreatic function related to diabetes identified. Stanford Medicine News Center.

  • Research Highlight: F1000Prime Recomendation. Gloyn A, Thomsen S. 09 May 2016; DOI: 10.3410

• Alfa RW, Kim SK. 2016. Using Drosophila to discover mechanisms underlying type 2 diabetes. Disease Models and Mechanisms. 9(1):365-376.

• Pauerstein PT, Park KM, Peiris H, Wang J, Kim SK. 2016. Research Resource: Genetic labelling of human islet alpha cells. Molecular Endocrinology. 30(2):248-253.

• Leung TH, Snyder ER, Liu Y, Wang J, Kim SK. 2015. A cellular, molecular, and pharmacological basis for appendage regeneration in mice. Genes and Development. 29(20):2097-2107.

  • Research Highlight: 2015, How mice regrow ear tissue. Nature. 527, 136-137 doi:10.1038/527136d

• Chiou SH, Winters IP, Wang J, Naranjo S, Dudgeon C, Tamburini FB, Brady JJ, Yang D, Gruner BM, Chuang CH, Caswell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, Winslow MM. 2015. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas-9 mediated somatic genome editing. Genes and Development. 29(14):1576-85.

• Pauerstein PT, Sugiyama T, Stanley SE, McLean GW, Wang J, Martin MG, Kim SK. 2015. Dissecting human gene functions regulating islet development with targeted gene transduction. Diabetes. 64(8):3037-49.

• Alfa RW, Park S, Skelly KR, Poffenberger G, Jain N, Gu X, Kockel L, Wang J, Liu Y, Powers AC, Kim SK. 2015. Suppression of Insulin Production and Secretion by a Decretin Hormone. Cell Metab. 21(2):323-333.

  • Research Highlight: Crunkhorn S. 2015, Novel decretin hormone identified. Nature Reviews Drug Discovery. 14, 238 doi:10.1038/nrd4601

  • Research Highlight: 2015, Limostatin—a decretin—suppresses insulin production Nature Reviews Endocrinology. 11, 194 doi:10.1038/nrendo.2015.20

  • Editors' Choice: Gough NR. 2015, Finding the decretin hormone. Sci. Signal. 8, ec29

• Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. 2015. Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations. PLoS One 23, 10:e0118449. doi: 10.1371/journal.pone.0118449.

• Sebastiano V, Zhen HH, Derafshi BH, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, Schwertschkow A, Bauer G, Lisowski L, Kay MA, Kim SK, Lane AT, Wernig M, Oro AE. 2014. Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. Sci. Transl. Med. 6(264):264ra163.

• Benitez CM, Qu K, Sugiyama T, Pauerstein PT, Liu Y, Tsai J, Gu X, Ghodasara A, Arda HE, Zhang J, Dekker JD, Tucker HO, Chang HY, Kim SK. 2014. An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development. PLoS Genet 10:e1004645.

• Park S, Alfa RW, Topper SM, Kim GE, Kockel L, Kim SK. 2014. A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion. PLoS Genet 10:e1004555.

• Cao J, Ni J, Ma W, Shiu V, Milla LA, Park S, Spletter ML, Tang S, Zhang J, Wei X, Kim SK, Scott MP. 2014. Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila. Genetics 197:175-92.

• Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. 2013. Topical hypochlorite ameliorates NF-κB–mediated skin diseases in mice. J Clin Invest. 123:5361–5370

• Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann JF, Miyazaki S, Miyazaki J, Szot GL, Bottino R, Kim SK. 2013. Expansion and Conversion of Human Pancreatic Ductal Cells into Insulin-Secreting Endocrine Cells. eLife. 2:e00940

• Zhou JX, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, Kim SK, Bhushan A 2013. Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J Clin Invest. 123(11):4849–4858

• Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CVE, Gu G, and Kim SK. 2013. Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc. Natl. Acad. Sci. USA, 110(31):12691-6

• Arda HE, Benitez CM, Kim SK. 2013. Gene Regulatory Networks Governing Pancreas Development. Dev Cell. 25:5-13

• Goodyer WR, Gu X, Liu Y, Bottino R, Crabtree GR, Kim SK. 2012. Neonatal β-Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT. Dev Cell. 23:21-34

  • Previews : Kragl M, Lammert E. 2012. Calcineurin/NFATc Signaling: Role in Postnatal β-Cell Development and Diabetes Mellitus. Dev Cell. 23:7-8

• Benitez CM, Goodyer WR, Kim SK. 2012. Deconstructing Pancreas Developmental Biology. Cold Spring Harb Perspect Biol. 4:a012401

• Kim SK. 2012. Gut insulin from Foxo1 loss. Nat Genet. 44(4):363-4

• Wang P, McKnight KD, Wong DJ, Rodriguez RT, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang HY, Kim SK. 2012. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 21(12):2273-87

• Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK. 2011. PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature. 478(7369):349-55

• Park S, Bustamante EL, Antonova J, McLean GM, Kim SK. 2011. Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm is Regulated by Notch Signaling. PLoS Genetics. 7(8):e1002241.

• Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerød A, Børresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY. 2011. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 43(7):621-9.

• Wang P, Rodriguez RT, Wang J, Ghodasara A, Kim SK. 2011. Targeting SOX17 in Human Embryonic Stem Cells Creates Unique Strategies for Isolating and Analyzing Developing Endoderm. Cell Stem Cell. 8(3):335-46.

• McKnight KD, Wang P, Kim SK. 2010. Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell. 6(4):300-8.

• Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, and Kim SK. 2009. Polycomb protein Ezh2 regulates pancreatic ß-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes & Development. 23(8):975-85

• Sugiyama T and Kim SK. 2008. Fluorescence-activated cell sorting purification of pancreatic progenitor cells. Diabetes Obes Metab. Suppl 4:179-85.

• S. L. Chavez, J. J. Meneses, H. N. Nguyen, S. K. Kim, R. A. Pera. 2008. Characterization of Six New Human Embryonic Stem Cell Lines (HSF7, -8, -9, -10, -12, and -13) Derived Under Minimal-Animal Component Conditions. Stem Cells Dev. 17(3):535-546.

• S. K. Karnik, H. Chen, G. W. McLean, J. J. Heit, X. Gu, A. Y. Zhang, M. Fontaine, M. H. Yen, and S. K. Kim. 2007. Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus . Science, 318(5851):806-809 . Full Text

• P. La, Y. Yang, S.K. Karnik, A.C. Silva, R.W. Schnepp, S.K. Kim, X. Hua. 2007. Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J. Biol.Chem., 282(43):31332-40.

• I.C. Rulifson, S.K. Karnik, P.W. Heiser, D. Ten Berge, H. Chen, X. Gu, M.M. Taketo, R. Nusse, M. Hebrok and S.K. Kim. 2007. Wnt signaling regulates pancreatic beta cell proliferation. Proc. Natl. Acad. Sci. USA, 104:6247-6252.

• L.C. Alonso, T. Yokoe, P. Zhang, D.K. Scott, S.K. Kim, C.P. O'Donnell, A. Garcia-Ocana. 2007. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes, 56(7):1792-801

• T. Sugiyama, R.T. Rodriguez, G.W. McLean and S.K. Kim. 2006. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc. Natl. Acad. Sci. USA , 104: 175-180.

• J.J. Heit, Å.A. Apelqvist, X. Gu, M.M. Winslow, J.R. Neilson, G.R. Crabtree and S.K. Kim. 2006. Calcineurin/NFAT signaling regulates pancreatic ß-cell growth and function. Nature, 443: 345-349.

• J.J. Heit, S.K. Karnik, and S.K. Kim. 2006. Intrinsic regulators of pancreatic ß-cell proliferation. Annual Reviews of Cell and Developmental Biology, 22: 311-338.

• T. Akasaka, S. Klinedinst, K. Ocorr, E.L. Bustamante, S.K. Kim and R. Bodmer. 2006. KATP channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc. Natl. Acad. Sci. USA, 103: 11999-12004.

• J.R. Arron, M.M. Winslow, A Polleri, C.P. Chang, H. Wu, X. Gao, J. R. Neilson, L. Chen, J.J. Heit, S.K. Kim, N. Yamasaki, T. Miyakawa, U. Franke, I.A. Graef, and G.R. Crabtree. 2006. NFAT dysregulation by increased dosage of DSCR1 and DYRK1 on chromosome 21. Nature, 441: 595-600.

• N.G. Smart, Å.A. Apelqvist, X. Gu, E.B. Harmon, J.N. Topper, R.J. MacDonald, and S.K. Kim. 2006. Conditional expression of Smad7 in pancreatic ß-cells disrupts TGF-ß signaling and induces reversible diabetes mellitus. PLoS Biol., 4: e39.

• S.K. Karnik, C.M. Hughes, X. Gu, O. Rozenblatt-Rosen, G.W. McLean, Y. Xiong, M. Meyerson, and S.K. Kim. 2005. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl. Acad. Sci. USA 102: 14659-14664.

• Y. Hori, X. Gu, X. Xie, and S.K. Kim. 2005. Differentiation of Insulin-Producing Cells from Human Neural Progenitor Cells. PLoS Med., 2: e103.

• J.J. Heit and S.K. Kim. 2004. Embryonic stem cells and islet replacement in diabetes mellitus. Pediatric Diabetes, Suppl 2: 5-15.

• E.B. Harmon, Å. Apelqvist, N. Smart, X. Gu, D. Osborne, and S.K. Kim. 2004. GDF11 modulates NGN3+ islet progenitor cell number and promotes ß-cell differentiation in pancreas development. Development, 131: 6163-6174.

• S.K. Kim and E.J. Rulifson. 2004. Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature 431: 316-420.

• Y. Hori, I.C. Rulifson, B.C. Tsai, J.J. Heit, J.D. Cahoy, and S.K. Kim. 2002. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc. Natl. Acad. Sci. USA 99: 16105-16110.

• S.K. Kim and R. MacDonald. 2002. Signaling and transcriptional regulation in the developing pancreas. Current Opinion in Genetics & Development 12: 540-547.

• S.K. Kim. 2002. "Pancreatic Islet Cell Replacement: Successes and Opportunities" in Reparative Medicine: Growing Organs and Tissues, J.D. Sipe, C.A. Kelley, and L.A. McNichol, eds., Ann. N.Y. Acad. Sci. 961: 1-3.

• E.J. Rulifson, S.K. Kim, and R. Nusse. 2002. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science, 296: 1118-1120.

• S.K. Kim, L. Selleri, J.S. Lee, A. Zhang, X. Gu, Y. Jacobs, and M.L. Cleary. 2002. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nature Genetics, 30: 430-435.

• E. Harmon, A. Ko, and S.K. Kim. 2002. Hedgehog signaling in gastrointestinal development and disease. Current Molecular Medicine 2: 67-82.

• S.K. Kim and M. Hebrok. 2001. Intercellular Signals Regulating Pancreas Development and Function. Genes & Development, 15: 111-127.

• M. Hebrok, S.K. Kim, B. St.-Jacques, A.P. McMahon, and D. A. Melton. 2000. Regulation of pancreas development by Hedgehog signaling. Development, 127: 4905-4913.

• S.K. Kim, M. Hebrok, E. Li, S. P. Oh, H. Schrewe, E. B. Harmon, J. S. Lee, and D. A. Melton. 2000. Activin receptor patterning of foregut organogenesis. Genes & Development, 14: 1866-1871.

• M. Hebrok, S.K. Kim, and D. A. Melton. 1999. Effects of hedgehog signaling on pancreas development. Falk Symposium 113, Conference Proceedings. “Cytokines and homeostasis in the gastrointestinal tract.” pp. 379-387.

• M. Hebrok, S.K. Kim, and D.A. Melton. 1999. Screening for novel pancreatic genes expressed during embryogenesis. Diabetes, 48: 1550-1556.

• M. Hebrok, S.K. Kim and D. A. Melton. 1998. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes and Development, 12: 1705-1713.

• S.K. Kim and D. A. Melton. 1998. Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. USA 95: 13036-13041.

• S.K. Kim, M. Hebrok and D. A. Melton. 1997. Pancreas development in the chick embryo, in Cold Spring Harbor Symposia on Quantitative Biology. 62: 377-383.

• S.K. Kim, M. Hebrok and D. A. Melton. 1997. Notochord to endoderm signaling is required for pancreas development. Development, 124: 4243-4252.

• S.K. Kim and G. Demetri. 1996. Chemotherapy and Neutropenia. Hematology and Oncology Clinics of North America 10: 377-395.

• S.K. Kim. 1992. C-factor: An intercellular signaling protein required for fruiting body morphogenesis of Myxococcus xanthus. Doctoral thesis. Department of Biochemistry, Stanford University.

• S.K. Kim, A. Kuspa and D. Kaiser. 1992. Control of cell density and pattern by intercellular signaling in Myxococcus development. Annual Reviews of Microbiology, 46:117-139.

• S.K. Kim. 1991. Intercellular signaling in Myxococcus development: the role of C-factor. Trends in Genetics, 7: 361-365.

• S.K. Kim and D. Kaiser. 1991. C-factor has distinct aggregation and sporulation thresholds during Myxococcus development. Journal of Bacteriology, 173: 1722-1728.

• S.K. Kim and D. Kaiser. 1990. Cell alignment required in differentiation of Myxococcus xanthus. Science, 249: 926-928.

• S.K. Kim and D. Kaiser. 1990. Cell motility is required for the transmission of C-factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. Genes and Development, 4: 896-904.

• S.K. Kim and D. Kaiser. 1990. Purification and properties of Myxococcus xanthus C-factor, an intercellular signaling protein. Proc. Natl. Acad. Sci. USA 87: 3635-9.

• S.K. Kim and D. Kaiser. 1990. C-factor: A cell-cell signaling protein required for fruiting body morphogenesis of Myxococcus xanthus. Cell, 61: 19-26.

• R. Lagos, R.-Z. Jiang, S. Kim and R. Goldstein. 1986 Rho-dependent transcription termination of a bacterial operon is antagonized by an extrachromosomal gene product. Proc. Natl. Acad. Sci., USA 83: 1561-5.